e-Lit Jazz

LIT-PC3137-Oxygen therapy.indd

Lit Lunch 2/6/14

The putative eukaryotic translation initiation factor 5A (eIF5A) is a highly conserved and essential protein present in all organisms except bacteria. To be activated, eIF5A requires the conversion of a specific residue of lysine into hypusine. This hypusine modification occurs posttranslationally in two enzymatic steps, and the polyamine spermidine is the substrate. Despite having an essential...

Lit Lunch – December 6th

A major limitation of high-throughput DNA sequencing is the high rate of erroneous base calls produced. For instance, Illumina sequencing machines produce errors at a rate of ∼0.1–1 × 10 per base sequenced. These technologies typically produce billions of base calls per experiment, translating to millions of errors. We have developed a unique library preparation strategy, “circle sequencing,” w...

On Jazz

The question of what is meant by "jazz" seems to mock the clear-cut definitive answer. Just as the historical origins of the form arc disappearing into the fog of the recent past, so its range is disappearing within its ambivalent use at the present moment. For the purpose of providing a crude orientation, one could concede that it is that type of dance music--whether it be used in an unmediate...

Lit Review – 9 - 20 - 16

Heat shock proteins (HSP) are expressed at high levels in cancer and form a fostering environment that is essential for tumor development. Here, we review the recent data in this area, concentrating mainly on Hsp27, Hsp70, and Hsp90. The overriding role of HSPs in cancer is to stabilize the active functions of overexpressed and mutated cancer genes. Thus, elevated HSPs are required for many of ...